Mark Sircus
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 In reality, problems with magnesium supplementation usually occurs when the magnesium in the IV is given too rapidly and in too high of a dose or both.
There is the balance of calcium to magnesium to be kept in the range of 1:1 to 2:1. If more magnesium than calcium is taken then you are going to upset your calcium balance. This is not an issue though for people whose dairy intake is high. Most people today are getting too much calcium and not enough magnesium.
The ratio of minerals and vitamins to each other is important. |
| Levels of intracellular glutathione have been shown to increase by 16% in T-cell cultures at concentrations of 10- 100 fM (concentrations achievable with oral and intravenous supplementation of ALA). Increases in glutathione levels seen with ALA administration are not only from the reduction of oxidized glutathione (one of the functions of ALA) but also from the synthesis of glutathione."
Cilantro: Mobilizes toxic metals from the central nervous system and other tissues. A researcher named Dr. |
| Many of the symptoms of Parkinson's disease can be overcome with high magnesium supplementation. In a trial with thirty epileptics, 450 mg of magnesium supplied daily successfully controlled seizures. Another study found that the lower the magnesium blood levels the more severe was the epilepsy.
Magnesium works best in combination with vitamin B. and zinc.
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Because of its nerve and muscle support, magnesium is helpful for nervousness, anxiety, insomnia, depression, and muscle cramps. Thus magnesium is also given as part of a treatment for autism or hyperactivity in kids.
Dr. |
| Zinc supplementation is associated with decreased oxidative stress and improved immune function, which may be among the possible mechanisms for its cancer preventive activity.
Zinc is essential for health. It is needed for the enzymes that regulate cell division, growth, wound healing, and proper functioning of the immune system. Zinc is an essential co-factor in a variety of cellular processes including DNA synthesis, behavioral responses, reproduction, bone formation, growth and wound healing. |
| Reduction of blood pressure with oral magnesium supplementation in women with mild to moderate hypertension. American Journal of Clinical Nutrition, Vol. 60, July 1994, pp. 129-35
20 Geleijnse, J.M., et al. Reduction in blood pressure with a low sodium, high potassium, high magnesium salt in older subjects with mild to moderate hypertension. British Medical Journal, Vol. 309, August 13, 1994, pp. 436-40
21 Manz, M., et al. Behandlung von herzrhythmusstorungen mit magnesium. Deutsche Medi Wochenschrifte, Vol. 115, No. 10, March 9, 1990, pp. 386-90
22 Iseri, Lloyd T., et al. |
| However, the method of supplementation is critical in terms of effective body utilization.
Magnesium is absorbed primarily in the distal small intestines or colon. Active uptake is required involving various transport systems such as the vitamin D-sensitive transport system. Since magnesium is not passively absorbed it demonstrates saturable absorption resulting in variable bioavailability averaging 35-40% of administered dose, even under the best conditions of intestinal health.
Magnesium levels in the body, presence of calcium, phosphate, phytate, and protein can affect rate of absorption. |
Gabriel Cousens
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 It may take three to six months after starting flax seed oil supplementation to see results.
FLAX VERSUS FISH OIL: FLAX WINS
Flax seed contains 18-24 percent omega-3, compared to the low content in fish of 0-2 percent. This is significant because many people mistakenly think that they need to eat fish in order to get the omega-3-derived EPA for heart and artery protection. Abundant research on the subject indicates that this is simply not true. The vegetarian flax seed has many major advantages over fish oil. |
Peter J. Whitehouse and Daniel George
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 Proof is lacking in the form of randomized controlled trials, although a recently published study appears to have confirmed the effect of folic acid supplementation on cognitive performance in human beings. Jane Durga et al. structured a randomized, double-blind, placebo-controlled study that took place between November 1999 and December 2004 in the Netherlands. Researchers randomly assigned 818 male and female participants aged fifty to seventy 800 milligrams daily oral folic acid or placebo for three years. |
Gabriel Cousens
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| In 1997, the results of a placebo-controlled trial conducted in China indicated that chromium supplementation might be beneficial in the treatment of Type-2 diabetes.165 In the study, 180 participants took either a placebo, 200 meg/day of chromium, or 1,000 meg/day of chromium (both of the latter groups in the form of chromium picoli-nate). At the end of four months, blood glucose levels were 15-19 percent lower in those who took 1,000 meg/day compared with those who took a placebo. Blood glucose levels in those who took 200 meg/day did not differ significantly from those who took a placebo. |
Gary Null and Amy McDonald
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 The Influence of Phosphatidylserine supplementation on Mood and Heart Rate When Faced with an Acute Stressor. Benton D; et al. Nutritional Neuroscience, 2001,4(3):169-178.
Young, healthy adults with higher than average neuroticism scores reported feeling less stressed when asked to perform a difficult mental arithmetic task after taking 300 mg of phosphatidylserine daily.
Kava Extract for Anxiety. Journal of Clinical Psychopharmacology, 2000, 20:1, 84-89.
A literature review and expert analysis revealed that kava extract is superior to placebo as a symptomatic treatment for anxiety. |
Gabriel Cousens
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| The Tree of Life 21-Day+ Program employs several routes to rem-ineralization: fresh organic plant foods eaten, juiced, and blended (including sea vegetables); superfood powder blends; and bioavailable mineral supplementation. Our means for getting nutrient-dense plant foods will be fully discussed in the recipe section, but here let us investigate key minerals that can help support and heal the pancreatic beta cells, improve insulin sensitivity, regulate blood glucose levels, and prevent or reverse diabetic complications. |
| One study showed that insulin sensitivity was increased by 34 percent with the use of arginine, versus 4 percent for a control group. supplementation of L-arginine can be beneficial for individuals who have increased AGEs and free-radical induced aging that accompanies poor control of blood sugar and insulin. In a clinical study done at the University of Vienna Department of Medicine, 1 gram of L-arginine was given twice daily to individuals who had oxidative stress as a consequence of poor blood sugar control. |
James Dowd and Diane Stafford
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 Most people need vitamin D supplementation to get the job done.
To estimate the amount of sun you need to make an adequate amount of vitamin D, follow these instructions from the Sun Exposure Times chart.
1. Look up your local UV index in real time at www.cpc.ncep .noaa.gov/products/stratosphere/uv_index/uv_annual.html or go to the Weather Channel at www.weather.com and type your zip code in the appropriate box. Your current forecast with a current UV index will appear.
2. Refer to the following chart and find your UVI (UV index) on the top row.
3. |
| Georgia got much better simply by taking adequate vitamin D and magnesium supplementation, making better food choices, and becoming more active.
In two months, she got much better on the Vitamin D Cure program, and you can, too. The upbeat message: you can not only stop disease, but you can actually reverse it!
Georgia's story isn't unusual at all; I see patients like her every day. Having taken care of adults and children with arthritis since 1995,1 have had more than forty thousand patient encounters that have taught me that all the symptoms and diseases Georgia experienced are preventable. |
| She began supplementation, came back to my office, and her new scores were 0-20-20-10-7. This says:
?She never needs assistance to move.
?Her relief from pain improved 75 percent.
?She feels more energetic—her fatigue has improved 80 percent, dropping from 100 to 20.
?She feels 85 percent better—she's experiencing much more restful sleep.
Now let's look at some people who followed the Vitamin D Cure at the Arthritis Institute of Michigan.
MARTA'S STIFFNESS
One doctor thought Marta, fifty-three, had fibromyalgia; another physician's diagnosis was rheumatoid arthritis. |
| To complete the vitamin D supplementation package, you must make the necessary dietary changes and/or take the right supplements to restore normal magnesium levels.
Magnesium restoration, unlike the vitamin D upgrade, can take many months. The problem is, you can't accurately assess your magnesium status very easily with commonly available blood tests. If you're assessing your magnesium level, you'll get more information from a written analysis of your eating patterns than you will from blood tests. |
| Some people, however, prefer to skip blood tests and proceed straight to vitamin D supplementation. This is perfectly acceptable, but it leaves you guessing why you may or may not have responded the way you expected. If you're not feeling better in two months or if you just want to know where you stand, you may want to go to your doctor to get tested. See The Right Vitamin D Tests beginning on page 207 for more information. |
| Magnesium replacement in vitamin D deficiency through diet or supplementation is critical and is as important as replenishing calcium stores.
Remember, if you have questions about your lab results, consult with the family physician or specialist (endocrinologist or rheuma-tologist) who's doing your evaluation. Let him or her know you're planning to take supplements. |
Stephen T. Sinatra, M.D.
See book keywords and concepts |
 As a practical matter, these tissues can make all the ribose they need and are not helped by ribose supplementation. Unfortunately, ribose made by these tissues cannot be moved into the blood for transport to other tissues where it is needed.
Other tissues, including the heart, skeletal muscle, nerve tissue, brain, and the like can only make enough ribose to manage their day-to-day needs when the cells are not stressed. Unfortunately for us, these cells lack the metabolic machinery they need to make ribose quickly when they come under metabolic stress such as oxygen deprivation. |
| When I encounter vegetarians in my practice, I insist that they consider not only vitamin B12 and coenzyme Q10 supplementation, but L-carnitine as well.
There are documented cases of people following strict macrobiotic diets that develop weakness, weight loss, and severe nutritional deficiencies, that evolve into disease states. It's also well established that both children and adults consuming primarily vegetarian-type foods tend to have lower concentrations of carnitine in their plasma compared to those eating foods rich in animal sources. |
| Like coenzyme Q10, dietary supplementation of L-carnitine increases its levels in the blood and tissues.
Now that we've discussed the dietary intake and biosynthesis of L-carnitine, let's examine its biological functions.
Biological Effects of L-Carnitine
The principal function of carnitine is to facilitate the transport of long-chain fatty acids across the inner mitochondrial membrane to begin the process called beta-oxidation we learned about in Chapter 3. |
| Compliance to supplementation was 95-96 percent for all groups. Exercise attendance was 84-90 percent and time spent in the target HR zone was 90-94 percent. All subjects twho were administered GPLC, tolerated it well"
The following dependent variables were used for comparison between groups:
1. Aerobic power (V02max)
2. Exercise time to fatigue
3. Anaerobic power (mean and peak power; total work)
4. Blood lipids (total cholesterol, HDL, LDL, triglycerides)
5. Blood nitric oxide production
6. Blood antioxidant and oxidative stress status
7. |
| Resting blood pressure and heart rate
This is the first human intervention study to combine carnitine supplementation and supervised exercise in relation to such exhaustive measurement to all of the variables listed above.
The results soundly support GPLC as demonstrating strong performance in the retention of muscle carnitine during and after strenuous physical activity as well as significantly affecting the production of nitric oxide (NO). See below chart "GPLC & Nitric Oxide Assays."
Nitric oxide (NO) is an important signaling molecule, promoting vasodilation. |
Gabriel Cousens
See book keywords and concepts |
| Generally, chromium supplementation at doses of about 200 meg/day, in a variety of forms for two to three months have been found in studies to be beneficial.
Herbal and Natural Teas
Caffeine elevates blood sugar by stimulating and aggravating the adrenal glucose axis, causing imbalanced and elevated blood sugars, and therefore keeps imbalancing the attempt of the healing diabetic body to achieve a normal physiology. Caffeine is also a diuretic and creates dehydration, which is a tendency in diabetes because the body is trying to rid itself of excess blood sugar by urination (diuresis). |
Michael T. Murray and Michael R. Lyon
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 When combined with weight training, creatine supplementation has been shown to increase muscle mass and improve leg strength, endurance, and power in both elderly and young subjects. Physical inactivity is a major reason why so many Americans are overweight.
Exercise has been shown to compensate for a reduced basal metabolic rate (BMR) due to calorie restriction.
We recommend a combination of aerobic, strength training, and flexibility exercises to see the full benefits of exercise. The time you spend exercising is a valuable investment toward good health.
8
Rev Up Your Metabolism
H 3. |
Ann M. Coulston and Carol J. Boushey
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 Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: A postintervention follow-up. JAMA. 290, 476-485.
272. Hartman, T. J., Albanes, D., Pietinen, P., Hartman, A. M., Rautalahti, M., Tangrea, J. A., and Taylor, P. R. (1998). The association between baseline vitamin E, selenium, and prostate cancer in the alpha-tocopherol, beta-carotene cancer prevention study. Cancer Epidemiol. Biomarkers Prev. 7, 335-340.
273. Fleshner, N., Fair, W. R., Huryk, R., and Heston, W. D. (1999). |
| Effect of dietary supplementation with very-long-chain n-3 fatty acids in patients with psoriasis. N. Engl. J. Med. 328, 1812-1816.
35. Wolk, A., Vessby, B., Ljung, H., and Barrefors, P. (1998). Evaluation of a biologic marker for dairy fat intake. Am. J. Clin. Nutr. 68, 291-295.
36. Smedman, A. E. M., Gustafsson, I. B., Berglund, L. G. T., and Vessby, B. O. H. (1999). Pentadecanoic acid in serum as a marker for intake of milk fat: relations between intake of milk fat and metabolic risk factors. Am. J. Clin. Nutr. 69, 22-29.
37. Turnlund, J. R. (1994). |
Dawson Church
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 For instance, conventional hormone replacement therapies have been shown to have negative side effects in the ten years since Weil penned this list (the National Women's Health Network calls hormone replacement "a triumph of marketing over science"11), while alternative medicine, through exercise and diet-based approaches, plus supplementation if necessary, have been shown to stimulate the body's hormonal production and balance. |
Michael T. Murray and Michael R. Lyon
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| Creatine supplementation augments the muscle growth stimulation of weight training, but without the weight training it has little, if any, benefit. Our dosage recommendation is based upon body weight. Take 1 gram of creatine for every 50 pounds of body weight before you work out. If you weigh 150 pounds your dosage would be 3 grams. If you suffer from any kidney or liver disease, please consult a physician before supplementing with creatine. |
Ann M. Coulston and Carol J. Boushey
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| Does vitamin E supplementation modulate in vivo arachidonate metabolism in human inflammation? Pharmacol. Toxicol. 61, 246-249.
49. Ruffin, M. T., Krishnan, K, Rock, C. L., Normolle, D., Vaerten, M. A., Peters-Golden, M., Crowell, J., Kelloff, G., Boland, C. R., and Brenner, D. E. (1997). Suppression of human colorectal mucosal prostaglandins: determining the lowest effective aspirin dose. J. Natl. Cancer Inst. 89, 1152-1160.
50. Krishnan, K., Ruffin, M. T., and Brenner, D. E. (1998). Clinical models of chemoprevention for colon cancer. Hem. One. Clin. N. Am. 12, 1079-1113.
51. Selhub, J. |
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