Textbook of Natural Medicine 2nd Edition Volume 1Michael T. Murray, ND See book keywords and concepts |
Over 100 million Americans now take dietary supplements on a regular basis. Despite the tremendous body of research supporting the use of nutritional supplementation, most medical experts and researchers have still not publicly endorsed nutritional supplementation even though 98% of them take supplements themselves.
Numerous studies have demonstrated that most Americans consume a diet inadequate in nutritional value. Comprehensive studies sponsored by the US government (HANES I and II, Ten State Nutrition Survey, USDA nationwide food consumption studies, etc. |
National Women's Health Network See book keywords and concepts |
Many people don't realize that just as pharmaceutical companies promote drugs, so too is there a whole industry out there developing, producing, and selling dietary supplements, herbs, and other alternative health care products. Alternative health care practitioners are subject to similar influences from these companies as conventional doctors are from drug companies. These practitioners may promote a product they've seen in ads or have received free samples of from the manufacturer. |
Elson M. Haas, M.D. See book keywords and concepts |
Various calcium formulae, such as calcium carbonate and calcium gluconate, are taken commonly as dietary supplements to attain adequate calcium levels. Many calcium salts are used as nutrient additives in enriched foods, especially grain products—cereals, flours, infant formulas, cornmeal, farina, noodles, and breads.
Calcium salts are also used as emulsifiers in evaporated milk, frozen desserts, and breads; as dough conditioners in baked goods; and as clarifying agents in sweets. |
Sheldon Saul Hendler See book keywords and concepts |
OVERVIEW: New Life for Lecithin
Lecithin has been one of the most popular dietary supplements for a long time. Claims and anecdotes abound regarding its ability to lower blood cholesterol levels, to protect against heart disease, to enhance memory and to increase energy levels, among other things. Many in the medical community have completely rejected any beneficial effects of lecithin as old wives' tales. Some actually become incensed at the mere suggestion that lecithin can lower blood cholesterol levels. |
Committee on Diet, Nutrition, and Cancer, Assembly of Life Sciences National Research Council See book keywords and concepts |
These recommendations apply only to foods as sources of nutrients— not to dietary supplements of individual nutrients. The vast literature examined in this report focuses on the relationship between the consumption of foods and the incidence of cancer in human populations. In contrast, there is very little information on the effects of various levels of individual nutrients on the risk of cancer in humans. Therefore, the committee is unable to predict the health effects of high and potentially toxic doses of isolated nutrients consumed in the form of supplements.
3. |
Ruth Winter See book keywords and concepts |
The chloride, citrate, gluconate, glycerate, hypophosphite, and sulfate are all used as dietary supplements and nutrients and are considered GRAS. Many forms are used in dyeing. Manganous salts are activators of enzymes and are necessary to the development of strong bones. They are used as nutrients and as dairy substitutes. Toxicity occurs by inhalation. Symptoms include languor, sleepiness, wakefulness, emotional disturbances, and Parkinson-like symptoms. |
Iron ascorbate, carbonate, chloride, citrate, fumarate, gluconate, lactate, oxide, phosphate, pyrophospate, sulfate, and reduced iron are dietary supplements. GRAS. Iron is potentially toxic in all forms. IRON AMMONIUM CITRATE • A salt for human or animal consumption. An anticaking agent that the FDA says should be less than 25 ppm. See Iron Salts. IRON CAPRYLATE, IRON LINOLEATE, IRON NAPHTHENATE, and IRON TALLATE • All are used in packaging. |
The proposal would prohibit the marketing of dietary supplements containing 8 mg or more of ephedrine alkaloids per serving. Labeling that recommends or suggests conditions of use that would result in an intake of 8 mg or more in a 6-hour period or a total daily intake of 24 mg or more also would not be allowed. The proposal would also require label statements instructing consumers not to use the product for more than seven days, and would not allow label claims for uses for which long-term intake would be necessary to achieve the purported effect. |
These experts suggested a number of steps the agency might take to reduce injuries associated with use of dietary supplements containing ephedrine alkaloids. See also Ephedrine.
EPHEDRINE • The alkaloid ephedrine is derived from the plant Ephedra equi-setina and others of the forty species of ephedra or produced synthetically. Ephedra has been used for more than five thousand years in Chinese medicine and has become more and more popular in Western medicine. |
National Women's Health Network See book keywords and concepts |
With this large number of older women, researchers are able to look for correlations among diet, exercise, hormone use, dietary supplements, and various serious health conditions. The Nurses Health Study provides information on nearly every topic addressed in this book. The two most significant findings are that breast cancer incidence rises with each year of ERT use and that women taking ERT are less likely to die of heart disease. |
Sheldon Saul Hendler and David Rorvik See book keywords and concepts |
A prediction of chromium (III) accumulation in humans from chromium dietary supplements. FASEB J. 1995; 9:1650-1657.
Stearns DM, Wise JP Sr, Patierno SR, Wetterhahn KE. Chromium (III) picolinate produces chromosome damage in Chinese hamster ovary cells. FASEB J. 1995; 9:1643-1649.
Stoecker BJ. Chromium. In: Shils ME, Olson JA, Shike M. Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 1999:277-282.
Verhage AH, Cheong WK, Jeejeebhoy. |
Earl Mindell See book keywords and concepts |
They require vitamins, minerals, herbs, and amino acids be labeled as dietary supplements. As such, these products must feature a Supplement Facts panel with information similar to the Nutrition Facts panels that appear on processed foods.
The Supplement Facts panel must include an appropriate serving/dosage size and information about 14 nutrients when present at significant levels, including vitamins A and C, sodium, calcium, and iron. Dietary ingredients that have no RDI/RDA must also be listed. |
John Heinerman See book keywords and concepts |
Mahuang is the main factor in numerous herbal energy formulas and dietary supplements marketed by the powerful health food and herb industries. Consumers should read the labels of such products to see whether or not they contain mahuang.
The FDA (Food and Drug Administration) has warned the public that over-consumption of herbal energy stimulants containing both mahuang and kola nut or guarana can induce heart attacks and damage nervous systems. |
Marion Nestle See book keywords and concepts |
Industry groups distributed this poster to health food stores during the 1993 campaign to overturn the FDA's restrictions on health claims for dietary supplements. Posters like this encourged people to lobby Congress to protect their "constitutional rights" to take supplements.
$250,000 for a supplement trade group, and to have said that "Utah companies are dominant players in the supplement industry and . . . there's no senator alive who wouldn't want to do what he could for that industry. |
Sheldon Saul Hendler and David Rorvik See book keywords and concepts |
DESCRIPTION
Androstenediol refers to two steroid isomers that are marketed as dietary supplements and mainly used by body builders. The two androstenediol isomers are delta4-andros-tenediol and delta5-androstenediol. The difference between the two isomers is in the position of the double bond in the cyclopentanoperhydrophenanthrene ring structure. Delta4-androstenediol has a double bond between carbons 4 and 5; delta5-androstenediol has a double bond between carbons 5 and 6.
Delta4-androstenediol is also known as 4-androstene-3beta, 17beta-diol and (3beta, 17beta)-androst-4-ene-3, 17-diol. |
Marion Nestle See book keywords and concepts |
As we shall see, DSHEA gave the industry everything it wanted and then some; it deregulated dietary supplements and undermined the FDA's regulatory authority over supplements and conventional foods as well. After DSHEA, the FDA could no longer take the kind of responsibility for ensuring the accuracy of information on product labels that consumers had come to expect. |
Sheldon Saul Hendler and David Rorvik See book keywords and concepts |
DESCRIPTION
19-Norandrostenedione refers to two steroid isomers that are marketed as dietary supplements and mainly used by body builders. The difference between the two 19-norandrostene-dione isomers is in the position of the double bond in the cyclopentanoperhydrophenanthrene ring structure. The del-ta4 isomer has a double bond between carbons 4 and 5; the delta5 isomer has a double bond between carbons 5 and 6.
The delta4 isomer is also known as 19-nor-4-androstene-3, 17-dione. The delta5 isomer is also known as 19-nor-5-androstene-3, 17-dione. |
Textbook of Natural Medicine 2nd Edition Volume 1Michael T. Murray, ND See book keywords and concepts |
Findings
Cheraskin & Ringsdorf's 15 year study of 13,500 subjects found that the healthiest individuals, meaning those with the least clinical symptoms and signs, were those who had consumed dietary supplements and eaten a diet nutritionally dense in nutrients relative to their caloric intake.
Nutritionally, density of the diet proved to be a key variable among the healthiest subjects. For example, Cheraskin & Ringsdorf discovered that the "healthiest" subjects had a mean vitamin C intake of 410 mg a day, a good portion of which was consumed from food. |
Sheldon Saul Hendler and David Rorvik See book keywords and concepts |
Lower doses, which are available as dietary supplements, are unlikely to have any desirable effect.
LITERATURE
Boiardi A, Picotti GB, Di Giulio AM, et al. Platelet met-enkephalin immunoreactivity and 5-hydroxytryptamine concentrations in migraine patients: effects of 5-hydroxy-tryptophan, amitriptyline and chlorimipramine treatment. Cephalalgia. 1984; 4:81-84.
Byerley WF, Judd LL, Reimherr FW, et al. 5-Hydroxytryptophan: a review of its antidepressant efficacy and adverse effects. J Clin Psychopharmacol. 1987; 7:127-137.
Cangiano C, Ceci F, Cascino A, et al. |
Textbook of Natural Medicine 2nd Edition Volume 1Michael T. Murray, ND See book keywords and concepts |
Also test dietary supplements one at a time.
Food and symptom diary
Have the patient record chronologically in a notebook all foods, liquids, supplements, moods, symptoms and reactions. The foods eaten throughout the day should be noted in pencil, or blue or black ink. Highlight or circle symptoms using colored ink so that those adverse reactions will stand out clearly. In 2-3 weeks a repetitive pattern of symptoms will be clearly visible, which allows for identification and elimination of the problematic foods or food combinations causing symptoms. |
Sheldon Saul Hendler and David Rorvik See book keywords and concepts |
Clinical studies on the phenylalanine hypothesis of affective disorder: urine and blood phenylacetic acid and phenylalanine dietary supplements. J Clin Psychiatry. 1986; 47:66-70.
Schulpis CH, Antoniou C, Michas T, Starigos J. Phenylalanine plus ultraviolet light: preliminary report of a promising treatment for childhood vitiligo. Pediatr Dermatol. 1989; 6:332-335.
Siddiqui AH, Stolk LM, Bhaggoe R, et al. L-phenylalanine and UVA irradiation in the treatment of vitiligo. Dermatology. 1994; 188:215-218.
Zhao G. |
volker schulz and Rudolf Hansel See book keywords and concepts |
Congress, 2002; Blumenthal, 2002). The slender shrub is distinguished by its very thin, woody spines about 5 mm in length. The dried root of eleutherococcus has a sharp, aromatic, slightly sweet taste. Lignan glycosides of the liriodendrin and coumarin types, including isofraxidin, have been identified as key constituents. Unlike true ginseng, however, eleuthero is not a species of Panax and contains only small concentrations of saponins (Bladt et al., 1990).
Eleuthero root was tested and developed in the former Soviet Union during the i96o's as a substitute for ginseng. |
Kronenberg and Fugh-Berman, 2003).
HI Other Herbs
Several other herbs used for gynecologic indications are listed in Table 7.1. Only some are available as proprietary products (Sect.7.5).
The aerial parts of the bugle weed (Lycopus spp., family Lamiaceae) are harvested just before the plant blooms. Tinctures and infusions of it were used in nineteenth-century America as a remedy for bleeding, especially nosebleeds and menorrhagia. Experimental pharmacologic studies have demonstrated antigonadotropic actions (Gumbinger et al, 1981; Winterhoff et al. |
U.S. between 1995 and 1999 (McGuffin, 2000).
As of 1999, the Food and Drug Administration (FDA) had recorded more than 2000 adverse events purportedly attributed to ephedra, but these were not evaluated as to degree of seriousness. All events resulting in illness or injury apparently associated with an ephedra product were listed. Of these, 29 deaths supposedly associated with ephedra or ephedrine were included. The validity of these figures was later questioned by a Congressional committee (Skinner, 1999). |
Dietary Supplement Health and Education Act of 1994 (DSHEA) (Blumenthal and Israelsen, 2000). In Canada, as note above, medicinal teas can be regulated as Natural Health Products and contain on their labels government-recognized claims and benefits.
H23I Medicinal Teas and Their Actions
Tea infusions can be prepared from single herbs or from herb mixtures. About 1000 single-herb teas and blends have been approved in Germany (Hiller, 1995). Common medicinal tea herbs and their indications are listed in Table 1.3 and 1.4. |
QU Drug Products
The Rote Liste 2003 lists well over 100 herbal products under the heading of Antitussives and Expectorants, consisting mostly of fixed combinations of active ingredients along with numerous products containing a single active ingredient (Tables 4.1-4.4). The 100 most commonly prescribed phytomedicines in Germany include 25 herbal antitussive-expectorants, consisting of 10 single-herb products and 15 combination products. |
Sheldon Saul Hendler and David Rorvik See book keywords and concepts |
The red yeast rice dietary supplements are standardized to 0.4% HMG-CoA reductase inhibitors, with 0.3% coming from lovastatin equivalents. A dose of 2,400 milligrams daily delivers 9.6 milligrams of HMG-CoA reductase inhibitors, including 7.2 milligrams of lovastatin equivalents. Red yeast rice typically comes in 600 milligram capsules. The usual dose has been 2,400 milligrams daily. See Precautions.
HOW SUPPLIED
Capsules — 400 mg, 600 mg Tablets, Extended Release — 600 mg
LITERATURE
Baens-Arcega L, Ardisher AG, Beddows CG, et al. |
Marion Nestle See book keywords and concepts |
The senator viewed as "frightening" FDA's 1993 supplement-labeling proposals; he said they meant that "purchase of high potency vitamins and minerals should be limited, access to herbal products should be restricted, and amino acids should be available only by prescription." The senator surely knew better—the proposals suggested doing so only when the products were labeled with unauthorized health claims—but he said, "If we let the FDA get away with this, next time it will be even easier for the agency to overregulate another industry. . . . |
Ruth Winter See book keywords and concepts |
Cuprous and potassium iodides are used in table salts; potassium iodide is in some drinking water; and potassium iodate is used in animal feeds. Dietary iodine is absorbed from the intestinal tract, and the main human sources are from food and water. Seafoods are good sources, and dairy products may be good sources if the cows eat enriched grain. Adult daily iodine requirement is believed to be 110 to 150 milligrams. Growing children and pregnant or lactating women may need more. |
Ralph W. Moss PhD See book keywords and concepts |
This included some herb-derived products such as evening primrose oil. Researchers at the University of California-San Diego found that such women were better educated, slimmer, etc. than their non-herb-using counterparts. In California at least, herbalism is chic (300).
Yet most people frankly admit that they are poorly educated on the topic of herbs. In the above study, only 19 percent of those taking supplements said they knew "quite a bit" about herbs, and only two percent said they knew "a great deal." When it comes to herbs, people generally don't consult their medical doctors. |